VOLUME 39 | ISSUE 1 | JANUARY-FEBRUARY 2019

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Hepatitis A immunity in Yozgat, Turkey

Çigdem Kader,a Ayse Yesim Göçmen,b Münire Islak Demir,a Nuriye Yalçin Çolak,a Sebnem Eren Gök,a Fatma Inci Arıkan,c Mehmet Yıldırım Sara,d Ayse Erbaya 

From the aDepartment of Infectious Diseases and Clinical Microbiology, Bozok Universitesi, Yozgat, Turkey; bDepartment of Medical Biochemistry, Bozok Universitesi, Yozgat, Turkey; cDepartment of Pediatrics, Bozok University, Faculty of Medicine, Yozgat, Turkey dDepartment of Medical Pharmacology, Hacettepe Universitesi, Ankara, Turkey

How to cite this article:

Kader C, Göcmen AY, Demir MI, Çolak NY, Gök SE, Arıkan FI, et al. Hepatitis A immunity in Yozgat, Turkey. Ann Saudi Med 2019; 39(1): 37-41.

Abstract

BACKGROUND: Since routine immunization could change the epidemiological profile of hepatitis A virus (HAV) infection in the future, it is important to determine the baseline immunity to HAV across Turkey.

 

OBJECTIVE: The aim of this study was to determine the seroprevalence of hepatitis A among individuals 6 years of age and older in Yozgat, Turkey.

 

DESIGN: Cross-sectional.

 

SETTING: Community in central region of Turkey.

 

PATIENTS AND METHODS: Questionnaires and blood specimens were collected and the presence of hepatitis A IgG antibodies against hepatitis A virus was determined quantitatively by ELISA.

 

MAIN OUTCOME MEASURES: The rates of hepatitis A immunity by age group.

 

SAMPLE SIZE: 1862.

 

RESULTS: Immunity to hepatitis A was 79.1% (n=1473). The mean (SD) age was 17.1 (14.7) years in the nonimmune group and 37.8 (19.5) years in the immune group (P<.001), and immunity increased with age. No significant difference in immunity rate was detected between gen.ders in children and adults. The seropositivity rate for subjects ages 6-19 years was lower than in subjects aged 20-96 years (52.2% versus 93.9%; P<.001).

 

CONCLUSION: A catch-up vaccination program is needed for persons aged 6-19 years in Yozgat.

 

LIMITATIONS: Single region data which can not be generalized. For this reason, a multi-centered study that can reflect the whole country is recommended.

 

CONFLICT OF INTEREST: None.

 

 

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