VOLUME 38 | ISSUE 5 | SEPTEMBER-OCTOBER 2018

Case Report Font size: Decrease font Enlarge font

Outcome with topical sirolimus for port wine stain malformations after unsatisfactory results with pulse dye laser treatment alone

Hebah Mohammadsalam Musalem,a Aljoharah Abdulaziz Alshaikh,a Lin M. Tuleimat,a Saad Alajlanb

From the aDepartment of Medicine, Alfaisal University, Riyadh, Saudi Arabia; bDepartment of Dermatology, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia 

How to cite this article:

Musalem HM, Alshaikh AA, Tuleimat LM, Alajlan S. Outcome with topical sirolimus for port wine stain malformations after unsatisfactory results with pulse dye laser treatment alone. Ann Saudi Med 2018; 38(5): 376-380. 

Abstract

We used a topical formulation of sirolimus for treating port wine stain (PWS). Although pulsed dye laser (PDL) is the current treatment of choice for PWS, fast neovascularization after treatment is a major drawback. With PDL therapy there has been insufficient improvement and frustrating side effects. The objective was to study the efficacy and safety of combining topical sirolimus with PDL as dual therapy in managing PWS. We report five PWS cases that were treated with PDL initially, followed by 0.5-1% topical sirolimus. With dual therapy there was significant improvement over a shorter duration. More published studies of topical sirolimus are needed to clarify the role of dual therapy in managing PWS associated with capillary malformations. We encourage further prospective and comparative studies with a larger sample size.

 

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