VOLUME 37 | ISSUE 4 | JULY-AUGUST 2017

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Abdullah Alrogy,a Abdullah S. Dirar,a Waleed Alrogy,b Hana Fakhoury,c Ali H. Hajeerd

From the aCollege of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; bCollege of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; cDepartment of Biochemistry and Molecular Biology, College of Medicine, AlFaisal University, Riyadh, Saudi Arabia; dDepartment of Basic Medical Sciences, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia

How to cite this article:

Alrogy A, Dirar AS, Alrogy W, Fakhoury H, Haheer AH. Reply to RE: Association of human leukocyte antigen-DRB1 with anti-cyclic citrullinated peptide autoantibodies in Saudi patients with rheumatoid arthritis. Ann Saudi Med 2017; 37(4): 338-339.

DOI: 10.5144/0256-4947.2017.338a

We would like to thank the authors of the letter commenting on our recent paper on the association between anti-CCP and the shared epitope status in Saudi patients with RA.1 Unfortunately, we do not have data on the smoking history of our patients. We agree that smoking is a risk for the development of anti-CCP.2 Nevertheless, studies on the epidemiology of smoking in Saudi Arabia suggest that smoking is more prevalent among Saudi males.3 Even though we had more females in our cohort, it might be difficult to decide whether this has direct influence on our findings. A bigger sample size with more males will be needed to answer this question. As for parity of the controls, again this information was not available and will need to be addressed in the future.

References

1. Alrogy A, Dirar A, Alrogy W, Fakhoury H, Hajeer A. Association of human leukocyte antigen DRB1 with anti-cyclic citrullinated peptide autoantibodies in Saudi patients with rheumatoid arthritis. Annals of Saudi Medicine 2017;37(1):488.

2. Bizzari S, Nair P, Al Ali MT, Hamzeh AR. Meta?analyses of the association of HLA?DRB1 alleles with rheumatoid arthritis among Arabs. International journal of rheumatic diseases 2016. DOI: 10.1111/1756-185X.12922.

3. Makrygiannakis D, Hermansson M, Ulfgren AK, Nicholas AP, Zendman AJW, Eklund A, et al. Smoking increases peptidylarginine deiminase 2 enzyme expression in human lungs and increases citrullination in BAL cells. Annals of the Rheumatic Diseases 2008;67(10):1488-1492.

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